Manuela Polydoro
Company: Muna Therapeutics
Job title: Head of Translational Medicine
Seminars:
Panel Discussion: Untangling the Future of Neuroimmunology Drug Development in the Wake of TREM2 Trial Results: To What Extent are Current TREM2 Models Fit For Purpose? 4:30 pm
Exploring how clinical validation of TREM2 will inform back translation and to what extent our current models still fit for purpose Navigating trial impact on preclinical model validation to better recapitulate neuroinflammatory pathology Evaluating the probable impact of inhibiting or stimulating microglia to reduce pathological neuroinflammation? How can we build on the next generation of…Read more
day: Conference Day One
Rescuing Neurodegeneration with TREM2 Agonism: a Small Molecule Approach Targeting Neuroimmunology in Alzheimer’s Disease 4:00 pm
Exploring a small molecule approach to enhance microglial function with TREM2 modulation, to improve neuroprotection Navigating implications on back translation to the clinic Outlining early biomarker data (GFAP, NFL,…) and implementation approach to further determine patient benefit Exploring patient stratification rationale to identify patients most likely to benefit from treatmentRead more
day: Conference Day One