Characterizing & Targeting Ferroptosis in Neurodegenerative Disease
Time: 11:45 am
day: Day Two
Details:
• Robust preclinical and clinical evidence suggests that ferroptotic-mediated cell death contributes to neurodegenerative disease
• Inhibition of 15-lipoxygenase to prevent ferroptosis addresses primary drivers of disease progression including, accumulation of lipid peroxides, redox imbalance, neuroinflammation, and neuronal loss
• Mitigation of lipid peroxidation also serves to address alpha-Synuclein pathology in vitro and in vivo
