Characterizing & Targeting Ferroptosis in Neurodegenerative Disease

Time: 11:45 am
day: Day Two


• Robust preclinical and clinical evidence suggests that ferroptotic-mediated cell death contributes to neurodegenerative disease

• Inhibition of 15-lipoxygenase to prevent ferroptosis addresses primary drivers of disease progression including, accumulation of lipid peroxides, redox imbalance, neuroinflammation, and neuronal loss

• Mitigation of lipid peroxidation also serves to address alpha-Synuclein pathology in vitro and in vivo