Setsu Endoh-Yamagami
Senior Scientist and Head of the iPSC-based Neural Pharmacology & Assay Group FUJIFILM Corporation
Seminars
Wednesday 15th April 2026
Neuroinflammation Signaling Cascade in Human iPSC-erived Neuron-astrocyte-microglia Tri-cultures
3:25 pm
- FUJIFILM research services will be introduced, emphasizing its strength in human iPSC-derived neuron-astrocyte-microglia tri-cultures
- Compared with conventional monoculture systems, the tri-culture system enables more sensitive and quantitative evaluation of cytokine release in response to stimuli such as LPS and α-synuclein
- Visualization of NF-κB subcellular localization allows elucidation of the signaling cascade propagating from microglia to astrocytes
- Combining signal cascade visualization with the tri-culture system is useful for mechanism-of-action analysis of anti-inflammatory reagents and other drugs of interest
