Ruxandra F. Sirbulescu
Assistant Professor of Neurology, Harvard Medical School; Principal Investigator, Vaccine and Immunotherapy Center, Mass General Mass General Brigham
Seminars
Friday 12th December 2025
Harnessing Peripheral B Cell Immunomodulation to Reduce Neuroinflammation and Promote Neuroprotection in CNS Injury and Degeneration
3:30 pm
- The involvement of peripheral B cells and T cells in propagating CNS inflammation and neurodegeneration, and the rationale for targeting these cells to reduce disease progression
- The novel concept of utilizing the regulatory properties of B cells in the context of CNS injury
- Leveraging a novel B cell–based immunomodulatory cell therapy to locally and systemically control inflammation, offering a targeted alternative to broad immunosuppression in neurotrauma and neurodegenerative disease
- Demonstrating therapeutic potential across multiple CNS indications, including traumatic brain injury, haemorrhagic stroke, and ALS, highlighting shared immune mechanisms that can be harnessed for neuroprotection
- Showcasing the full translational arc from mechanistic mouse studies to first-in-human clinical experience, illustrating how peripheral immune components can be developed into clinically viable CNS therapies
