Enya Paschen
Head of Preclinical Neuropharmacology Ulysses Neuroscience
Seminars
Wednesday 15th April 2026
From Immune Activation to Synaptic Dysfunction: Integrating Clinical & Preclinical Biomarker Insights in Depression
5:05 pm
- Human and rodent data demonstrate cross-species alignment of peripheral and central biomarkers linking immune signalling to neuronal dysfunction
- The back-translational IFN-α rodent model of depression shows that peripheral immune activation drives central neuroinflammation, alters neuroplasticity and induces depressive-like phenotypes, recapitulating clinically relevant features
- Integrated biomarker readouts strengthen the translational value of preclinical platforms for CNS drug discovery and enable assessment of target engagement and disease progression
