Daniel Wilton
Postdoctoral Research Fellow, Boston Children’s Hospital Harvard Medical School
Dr. Wilton completed a degree in Biochemistry at the University of Birmingham before earning a PhD at University College London in the laboratories of Professors Rhona Mirsky and Kristjan Jessen. During this time, he investigated the role of transcription factors in the Schwann-cell response to peripheral nerve injury, with a particular focus on how these regulators influence cellular plasticity.
His current research centres on the contribution of complement signalling and microglial function to the pathogenesis of Huntington’s disease. Using molecular, cellular, and behavioural approaches, Dr. Wilton is exploring whether inappropriate activation of microglia and the complement cascade drives aberrant synaptic pruning and, ultimately, accelerates disease progression.
Seminars
- Demonstrating how brain specific disease pathologies can potentially be detected in CSF and blood and how new imaging and molecular techniques could enhance this
- Developing specific tools to monitor neuroimmune markers and showing how they can be employed across neuroinflammatory and neurodegenerative conditions
- Highlighting the importance of early detection through sensitive diagnostic biomarkers, and the ways in which standardized collections and discovery biomarker studies are supporting this.
