TLR Pathway Modulation as a Lens on Microglial Dysfunction & Considerations for Innate Immune Targets
- The discovery and characterization of the CNS-penetrant IRAK4 inhibitor BIO- 8169 previously positioned for neuroimmune and inflammatory models
- How TLR pathway modulation reveals the potential trade-offs in therapies targeting CNS-innate immunity, such as the balance between phagocytic function and cytokine production
- Insights from the BIO-8169 discovery program on how targets can be prioritized and evaluated against complex microglial phenotypes and disease-specific inflammatory signatures