Targeting the Complement Pathway to Modulate Neuroinflammation in Neurodegenerative Disorders
- Complement activation is a key aspect of the neuroimmunological response to neurodegenerative disorders
- Glial cell reactivity is modulated by multiple complement system components that could be leveraged for therapeutic benefit
- Brain-penetrant complement therapeutics: efforts to develop a small molecule inhibitor of C3aR to overcome the limitations of antibody-based complement inhibitors
- Evaluating pharmacodynamic biomarkers of C3aR inhibition in preclinical models of neurodegeneration