Releasing the Microglial Brake: CD33 Modulation as a New Route to Restore Protective Immunity in Alzheimer’s Disease
- Unlock a previously underexploited microglial pathway to help restore homeostatic, disease-resolving activity without relying solely on TREM2-centric strategies
- Enables a more direct and tractable mechanism for restoring microglial phagocytosis and immune balance, supporting clearer translation from biology to therapeutic design
- Strengthen the foundation for precision microglial therapeutics by broadening the set of actionable immune checkpoints that shape microglial behaviour across disease stages