Robert Baloh

Robert Baloh

Company: pRED at Roche

Job title: VP, Global Head of Research in Neuroscience & Rare Diseases

Seminars:

Live Speaker Q&A 12:35 pm

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day: Day Two

Role of C9orf72 in Inflammation & Neurodegeneration 12:10 pm

• Repeat expansions in C9orf72 are the major genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia • Loss of function of C9orf72 in dendritic cells drives an autoinflammatory state that includes STING activation of type I IFN signaling • Microglia lacking C9orf72 have an altered response to aging and amyloid plaque accumulation • Endolysosomal…Read more

day: Day Two

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