Robert Baloh
Company: pRED at Roche
Job title: VP, Global Head of Research in Neuroscience & Rare Diseases
Seminars:
Live Speaker Q&A 12:35 pm
day: Day Two
Role of C9orf72 in Inflammation & Neurodegeneration 12:35 pm
• Repeat expansions in C9orf72 are the major genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia • Loss of function of C9orf72 in dendritic cells drives an autoinflammatory state that includes STING activation of type I IFN signaling • Microglia lacking C9orf72 have an altered response to aging and amyloid plaque accumulation • Endolysosomal…Read more
day: Day Two