Pascal Sanchez

Pascal Sanchez

Company: Denali Therapeutics

Job title: Director, Translational Sciences

Seminars:

Live Speaker Q&A 3:50 pm

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day: Day One

Metabolic Perturbations of Phagocytic Microglia in Alzheimer’s Disease Mouse Model 3:00 pm

• Deep-phenotyping analysis of brain-sorted microglia reveals profound transcriptomic perturbations in line with the notion that microglia response is largely mediated by amyloid-β pathology in AD • Accumulation of fibrillar Aβ in microglia is directly associated with a dramatic increase of various lipids, • Implications for therapeutic avenues targeting microgliaRead more

day: Day One

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