Pascal Sanchez
Company: Denali Therapeutics
Job title: Director, Translational Sciences
Seminars:
Live Speaker Q&A 3:50 pm
day: Day One
Metabolic Perturbations of Phagocytic Microglia in Alzheimer’s Disease Mouse Model 3:00 pm
• Deep-phenotyping analysis of brain-sorted microglia reveals profound transcriptomic perturbations in line with the notion that microglia response is largely mediated by amyloid-β pathology in AD • Accumulation of fibrillar Aβ in microglia is directly associated with a dramatic increase of various lipids, • Implications for therapeutic avenues targeting microgliaRead more
day: Day One