Leveraging Well-Understood Peripheral Immune Targets to Advance our Understanding of Microglial Biology in the CNS

Time: 11:00 am
day: Day Two


  • Understanding how to modulate pathways that are well characterised into cell types will less well understood biology to expand therapeutic capabilities
  • Applying the role of the receptors for the Fc region of immunoglobulins (FcRs) and downstream Bruton’s Tyrosine Kinase (BTK), which are well-understood in the peripheral immune system, to the CNS to expand target potential for neurodegenerative diseases
  • Understanding the importance of how antibodies and immune complexes modulate microglia function in neurological diseases and antibody therapeutics which engage Fc receptors to improve therapeutic development