Post-Conference Workshop Day

Workshop A: Targeting Inflammasome-Mediated Inflammatory Pathways in Neurodegenerative Diseases


Neuroinflammation and neurodegeneration are associated with abnormal deposition of aggregated host proteins, such as amyloid, α-synuclein, and prions, which can activate inflammasomes. Their activation induces an innate immune response involving the prominent innate immune cells in the brain for inflammasome activation, microglia. Additional CNS-resident cell types including astrocytes and neurons, as well as infiltrating myeloid cells from the periphery, also express and activate inflammasomes.

Attend this workshop to:

  • Discuss current understanding of the role of inflammasomes in common neurodegenerative diseases of the brain
  • Highlight inflammasome-targeted strategies that may potentially treat these diseases
  • Review the current efforts to target the inflammasome for neurodegenerative diseases

Workshop Leader:

Matt Havrda - Dartmouth

Matthew Havrda
Assistant Professor
The Geisel School of Medicine at Dartmouth

Workshop B: Battling the Blood-Brain Barrier in Neuroimmunological Diseases


Targeting neuroimmunological mechanisms in the brain involves overcoming a huge challenge, the blood-brain barrier. The blood-brain barrier may be compromised in certain disease states, which may also impact delivery of therapeutics.

At this workshop, you will:

  • Study the latest research in blood brain barrier biology associated with chronic neuroinflammation
  • Discover how this may affect drug transport to CNS targets
  • Discuss the technologies under development to cross, or bypass, the blood-brain barrier

Workshop Leader:

Eduard Urich - Roche

Edward Ulrich
Principal Scientist