Post-Conference Workshop Day
Workshop A: Targeting Inflammasome-Mediated Inflammatory Pathways in Neurodegenerative Diseases
Neuroinflammation and neurodegeneration are associated with abnormal deposition of aggregated host proteins, such as amyloid, α-synuclein, and prions, which can activate inflammasomes. Their activation induces an innate immune response involving the prominent innate immune cells in the brain for inflammasome activation, microglia. Additional CNS-resident cell types including astrocytes and neurons, as well as infiltrating myeloid cells from the periphery, also express and activate inflammasomes.
Attend this workshop to:
- Discuss current understanding of the role of inflammasomes in common neurodegenerative diseases of the brain
- Highlight inflammasome-targeted strategies that may potentially treat these diseases
- Review the current efforts to target the inflammasome for neurodegenerative diseases
The Geisel School of Medicine at Dartmouth
Workshop B: Battling the Blood-Brain Barrier in Neuroimmunological Diseases
Targeting neuroimmunological mechanisms in the brain involves overcoming a huge challenge, the blood-brain barrier. The blood-brain barrier may be compromised in certain disease states, which may also impact delivery of therapeutics.
At this workshop, you will:
- Study the latest research in blood brain barrier biology associated with chronic neuroinflammation
- Discover how this may affect drug transport to CNS targets
- Discuss the technologies under development to cross, or bypass, the blood-brain barrier