Media Library

Richard Ransohoff
Venture Partner
Third Rock Ventures

Where do you think the field needs to focus for success?

You have to define success first and the success that matters to me is making a difference for patients. So, where I think the field needs to focus is derived from the three main challenges. So, one is to develop a set of models that gives you some confidence going into the clinic. And here we will need an integrated combination of in vitro and in vivo models. So, that’s one area of focus. The other is to replicate in astrocytes and OPCs, the blood brain barrier cells and pericytes as well. We need to develop an understanding of the circumstances in which these cells play a role in neurodegenerative diseases. That understanding must start with germline disease genetics...